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Abstract
Impact of Immunologic Discoveries on the Vaccine
The spike glycoprotein (S1) interacts with host cell epithelial Angiotensin-Converting Enzyme-2 (ACE-2) receptors. The nano-luciferase-based assay shows that the virus’s 1 protein has a strong binding affinity with the ACE-2 receptors. Reports illustrate the S-protein antigenic epitope of SARS-CoV-2 binds with the TLR4/ MD-2 complex by strong molecular bonding interactions. The pool of miRNA based studies shows that TMPRSS2 acts as promising regulators for the SARS-CoV-2 entry checkpoint. Recent report stated that the AT1R phosphorylates JAK2 in the lung cells, which activates STAT-3 transduction to the nucleus.
Not only I discovered vaccine AZEE CRA 01, immune cell principles and methods of vaccination but also B cells have two components. B cells synthesis both MHC I, and MHC II. CD4 interacts with MQ, MHC II, CD8 Interacts with DC, MHC I, and B cells interacts with both MHC I, and MHC II, and Th2 and Tc1 (CD4 and CD8).
In these original articles I report the pandemics and immune cells, immunologic clearance and immune mechanisms, the discovery process: innovation and immunology, zelalem kiros bitsue and his vaccine discoveries, zelalem kiros bitsue and his immunologic discoveries, vaccine discovered and mechanisms of action 1of 2.
Published Date: 2023-01-27; Received Date: 2022-12-22