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Changes in lipid profile of rat plasma after chronic administration of Laghobanondo Rosh (LNR) - an ayurvedic formulation

Masuma Siddiqua, Kaiser Hamid, Mohammad Harun Ar Rashid, Mst. Sakina Akther, MSK Choudhuri

In this study, the lipid profile of rats’ plasma was measured after chronic administration of LNR usually used in the treatment of pandu (anaemia).The animal used for this research work was albino rats (Rattus novergicus: Sprague-Dawley strains) and LNR was administered per oral route at a dose of 100mg/kg body weight, once daily, up to 45 days for all the experiments. Forty rats, equally of both sexes, were randomly grouped into four where one male and one female group were used as control and other groups were used as test. LNR remarkably decreased plasma triglycerides in both male and female rats and it was statistically very highly significant (p=0.001***). Similar trend of result was noticed incase of total cholesterol in both sexes of the animal but it was not statistically significant (male, p=0.296, female, p=0.511). On the other hand, a reverse trend in the result was observed in case of VLDL, LDL and HDL. In case of LDL, the increase in male rats was statistically significant (p=0.047*) but in female rats it was statistically insignificant (p=0.506). The increase in VLDL and HDL was statistically insignificant in the both male and female rats.