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Abstract
Formulation and Development of Taste Masked Orally Disintegrating Tablets of Perindopril Erbumine by Direct Compression Method
The aim of current study was to formulate and evaluate taste masked orally disintegrating tablets of Perindopril Erbumine. Taste masking was done by using Eudragit E 100 in the ratio of 1:3 (drug:polymer) by mass extrusion method. The preliminary batches were prepared by using different superdisintegrants like Ac-Di-Sol, Primogel, Tulsion-335 and Tulsion-339. From the preliminary study it was found that orodispersible tablets containing Ac-Di- Sol showed better disintegration time and it was considered for further studies. A 32 full factorial design was applied to optimize the formulations, nine batches were prepared and evaluated. It was observed from the evaluations that the batch A2 showed the best disintegration time and also completes drug release within five minutes. Hence it was concluded that orally disintegrating tablets of Perindopril Erbumine can be successfully formulated using Ac-Di-Sol.