This research consists in studying the economic and financial profitability of Islamic and conventional banks in 23 countries during the current crisis. For this purpose, we use a sample of 99 Islamic and 110 conventional banks during the 2005/2015 period. The Generalized Least Squares (GLS) dynamic panel is applied to measure the difference between Islamic and conventional banks in terms of economic and financial returns. The results showed that during the period of the financial crisis, the financial profitability of Islamic and traditional banks falls. Our results also demonstrated that the financial crisis adversely affects the profitability of conventional banks more than that of Islamic banks.