Capnocytophaga is a genus of Gram-negative bacteria as oral saprophytes in humans, dogs and cats. The incidence rate of Capnocytophaga was 0.67 infections per million population. Classical risk factor including liver disease, liver cirrhosis, asplenic, alcoholics or postsplenectomy. Most of the patients are bitten or scratched by a dog. Brain abscess due to Capnocytophaga only have few reports. With the advent of biological agent in recent two decades, increased infection secondary to anti-tumor necrosis factor-α was established. Herein, we reported a case of Capnocytophaga Species brain abscess after anti-tumor necrosis factor-α. Patient developed Capnocytophaga Species brain abscess after treatment course of adalimumab 40 mg twice monthly for more than one year. To the best of our knowledge, this is the first case of Capnocytophaga infection following adalimumab treatment.