Biochemistry & Analytical Biochemistry

Abstract

Biotechnology Congress 2021 : Biochemical studies on the effect of turmeric on breast cancer of mouses by Fayoum University

Soha Rania Mahoud

Chemoprevention is regarded as one of the most promising and realistic approaches in the prevention of toxic effects of carcinogenic compounds. In this study, we investigated the chemoprevention efficacy of turmeric for 120 days against a single dose of (10 mg/rat) 7, 12-dimethylbenz (a) anthracene (DMBA). 60 rats were divided into four groups, 15 for each: Group I: Control; Group II: Injected with DMBA that induces mammary carcinoma; Group III treated with 5% turmeric before and after injection with DMBA; Group IV treated with 5% turmeric only as Control 2 and the treatments were administered daily for 4 months. At the end of experiment, the animals were sacrificed under anesthesia and their sera were used for evaluation of markers of tumorigenicity (serum levels of Total Sialic Acid (TSA) and carcino-embryonic antigens), markers of endocrine derangement (serum prolactin and estradiol) and markers of oxidative stress (MDA for lipid peroxidation, nitric oxide and total antioxidant). The breast tissues were investigated for malignancy. Results showed statistically significant elevation of Malondialdhyde (MDA).