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Association of Genetic Polymorphisms in Tumour Necrosis Factor-Alpha (TNF-α- 308G/A) and Interleukin-6 (IL-6-174G/C and IL-6-634C/G) with Lung Cancer Risk: A Meta-Analysis

Yibo Guo, Xinshuai Wang, Xiang Yuan, Yiwen Liu, Wei Sun and Shegan Gao*

The aim of this study was to examine the association of Tumour Necrosis Factor-Alpha (TNF-α) and Interleukin-6 (IL- 6) gene polymorphisms with the risk of developing lung cancer. We searched several electronic databases, including PubMed and Excerpt Medica Database (EMBASE), for a total of 17 studies involving 4,094 cases and 4,988 controls, which were included in a meta-analysis. The effects of three polymorphisms, TNF-α-308G/A, IL-6-174G/C and IL- 6-634C/G, were evaluated. The pooled Odds Ratio (OR) with 95% Confidence Interval (95% CI) was calculated by RevMan software. Heterogeneity was also assessed. Based on our results, we found an association between the TNF-α-308G/A polymorphism and lung cancer risk under the dominant model (GG+GA vs. AA, OR=0.60, 95% CI: 0.40 to 0.89). For the IL-6-174G/C polymorphisms, the pooled ORs (95% CI) of GG/GC vs. CC, GG vs. GC/ CC, GC vs. CC, and GG vs. CC were 1.22 (1.02 to 1.46), 1.22 (1.01 to 1.48), 1.22 (1.01 to 1.48), and 1.12 (0.87 to 1.44), respectively. For the IL-6-634C/G polymorphisms, the pooled ORs (95% CI) of CC/CG vs. GG, CC vs. CG/ GG, and C vs. G were 1.04 (0.68 to 1.58), 0.69 (0.57 to 0.85), and 0.79 (0.67 to 0.93), respectively. The results of our analysis of these IL-6 polymorphisms revealed an association between IL-6 and lung cancer risk. This association, however, was not as strong as the association between TNF-α-308G/A polymorphisms and lung cancer risk. Because the current study was limited in sample size, further studies are needed to reveal more precise associations.

Published Date: 2022-04-04; Received Date: 2022-03-01