The feasibility of aquaculture effluent as irrigation water for Salicornia brachiata Roxb. was determined to access the effect of effluent on fresh biomass, dry biomass, nutrient content and uptake. A field experiment was conducted using split plot design (SPD) with three factors (S- Sources of irrigation, M-Methods of sowing, F-Levels of fertilizer) at Central Soil Salinity Research Station, Dhanti-Umbharat, Navsari, India. The fresh and dry biomass yield of Salicornia was higher with the application of aquaculture effluent water to sea water irrigation. An application of 125:75:50 RDF of NPK conspicuously increased the fresh and dry biomass yield. The interaction study between the aquaculture effluent irrigation and 125:75:50 RDF of NPK on the fresh and dry biomass yield was significant. The individual effect of aquaculture effluent and 125:75:50 RDF of NPK were significant in the plant primary and secondary nutrient content and uptake. Concomitantly, the interaction of aquaculture effluent irrigation and 125:75:50 RDF of NPK was significant in plant primary and secondary nutrient uptake. In completion of the analysis, there was 40-50% nutrient saving with using aquaculture effluent.