Journal of Nanomedicine & Nanotechnology

Abstract

Anti-bacterial Activity of Polyvinyl Pyrrolidone Capped Silver Nanoparticles on the Carbapenem Resistant Strain of Acinetobacter baumannii

Vishvanath Tiwari, Manoj Kumar Khokar, Monalisa Tiwari, Swati Barala and Manish Kumar

Acinetobacter baumannii has been identified by Infectious Diseases Society of America as one of the six pathogens that cause majority of hospital infections. Carbapenems are the most effective β-lactam antibiotics that are routinely prescribed by clinicians to patients infected with A. baumannii. Emergence of resistance against carbapenem makes it difficult to treat A. baumannii and is therefore a threat to public health. Therefore it is very important to find a suitable alternative to the carbapenem. In the present work we have tried to establish silver nanomaterial as an alternative to carbapenem resistant strain of Acinetobacter baumannii. Silver nanoparticles have been prepared without aggregation by a modified chemical reduction method; using ethylene glycol mono methyl ether as solvent and PVP as capping agent. Transmission electron microscopic study revealed silver nanoparticles in spherical shape with narrow size distribution. The average size of silver nanoparticles has varied by changing the metal precursor to capping agent ratio, and corresponding characteristic size dependent plasmonic properties were observed using UV-Vis spectroscopy. It was found that novel silver nanoparticles having particle diameter <10 nm exhibited a tremendous potential antibacterial activity against the carbapenem resistant strain of Acinetobacter baumannii. Therefore, PVP-capped silver nanoparticle can be developed as an alternative to carbapenem, the most prescribed antibiotic for the Acinetobacter baumannii infections.