Journal of Nanomedicine & Nanotechnology

Abstract

An Innovation Technique in Treatment of Chronic Clot by Nano Magnetic Ablating Particles

Abbas Moghanizadeh*

Despite the current success of intra-arterial stroke therapy, there remain many challenges for chronic clot. Treatment of chronic clot poses a variety of challenges for physicians because its therapeutic alternatives have become increasingly more complex and sophisticated over time. This study aims to propose a novel therapy for chronic thrombosis by the nano magnetic ablation process. Presented Nano Magnetic Ablation (NMA) process employs magnetic force to cut off the chronic clot by nano ferromagnetic particles as cutting tools. While magnetic field pressurizes nano magnetic particles, vertically, to penetrate on the chronic clot surface, the number of nano particles play the role of cutting tools (dose of nano particles) and the rotational speed of magnet provide the horizontal force to ablate the chronic clot. This ablating mechanism enables the nano magnetic particles to slide on the chronic clot surface resulting in removing chronic clot. Several parameters govern in NMA process including magnetic field, rotational speed, nano particles dosage and thrombolytic agents.

To evaluate the effect of significant parameters on nano magnetic ablation process (percentage of removal chronic clot weight as output parameter), experiments are design and carry outed based on full factorial method. The analysis of the experimental data confirm that nano magnetic ablation has a unique potential to remove chronic clot noninvasively. The results show that magnetic field, has significant effect on the weight of removal chronic clot, while the administration thrombolytic agent, streptokinase, dose not any significant effect on ablation chronic clot and increasing the number of magnetic ablating particles (dosage of nano particles) to only a certain level, enhances the ablating process.

Published Date: 2024-08-12; Received Date: 2019-11-04