Pharmaceutica Analytica Acta

Abstract

An Emergence of a MRAB: With Growing Necessity of Antibiotic Pharmacist in Infectious Era

Maria A, Somia G, Hina L, Ishrat I and Munawerah F

Multi-drug Resistant pathogens pose a serious challenge against lifesaving antimicrobials globally. MRAB (multi drug resistant Acinetobacter baumannii) has a capability for extensive adaptation of multi-drug resistance pattern particularly in immune compromised patients which became resistant to carbapenems beta lactamase antimicrobials. The objective of the study is to evaluate multidrug resistance pattern of A. baumannii among broad spectrum antimicrobials with intention to highlight the growing need of antibiotic pharmacist in south Asia to encounter such life threatening multidrug resistance pattern. For the purpose of this study MRAB isolates with sensitivity and resistance pattern carefully evaluated by hospital pharmacist to determine such pattern with rationale utilization of therapy. Resulting data of about 146 isolates of MRAB interpreted by pharmacist which shows about 78% isolates were resistant to more than four broad spectrum antimicrobials. Amoxicillin has been resistant to 90%, Piperacillin 67%, third generation cephalosporin 92% with 75% of fourth generation cefepime, carbapenems 67%, aminoglycosides 75%, quinolones 54% and Polymyxin B 47% resistance respectively. This retrospective studies drawn conclusion that the effective utilization with evaluation of adaptive drug resistance can encounter threats associated with multidrug resistance pathogens and pharmacist can imparts key role in rationale utilization of antimicrobials with growing concern of implementation of specialty role in healthcare sector of south Asia.