Pharmaceutica Analytica Acta

Abstract

Allergic March – The Ways of Evolution from Simple to Complex

Sur Genel, Sur M Lucia, Sur Daniel, Coroian Aurelia and Floca Emanuela

The prevalence of allergic diseases is increasing worldwide in last decades.The ISAAC (International Study of Asthma and Allergies in Childhood) study suggested that the prevalence of allergy is between 6 and 12% in children. The natural history of allergic manifestations characterized by an age-related sequence of clinical symptoms and conditions is known as allergic march.Thus allergic march represents the evolution from cow’s milk protein allergy and atopic dermatitis to allergic rhinitis and asthma. Peak incidence of atopic dermatitis and cow’s milk protein allergy is found in the first two years of life. These children are at increased risk of developing other allergic diseases such as asthma and allergic rhinitis. Gastrointestinal and skin manifestations in association with respiratory and sometimes systemic events have an important impact on child development in terms of weight, stature and psychomotor, and later on the social integration of the patient .It is important to highlight natural evolution of allergic diseases both to predict a child’s risk with atopic dermatitis to develop allergic rhinitis or asthma, and also to establish timely therapeutic measures to influence or stop the development of allergic manifestations.