Journal of Nanomedicine & Nanotechnology

Abstract

Advancing Nanotoxicology through Systems Biology: Unraveling Mechanisms for Nanomaterial Hazard and Risk

Jianbo Sarah*

Nanotechnology has revolutionized various industries, offering unparalleled opportunities for innovation. However, concerns about the potential adverse effects of engineered nanomaterials on human health and the environment have prompted the emergence of nanotoxicology as a critical field of study. Traditional toxicological approaches often struggle to fully elucidate the complex interactions between nanomaterials and biological systems. In response, systems biology has emerged as a promising framework to unravel the mechanisms underlying nanomaterial toxicity. This article discusses the integration of systems biology into nanotoxicology, highlighting its potential to provide a mechanistic understanding of nanomaterial hazard and risk. We explore emerging approaches such as multi-omics profiling, network-based analysis, and predictive modeling, and discuss their applications in deciphering the intricate biological responses elicited by nanomaterial exposure. Despite challenges, the convergence of nanotechnology and systems biology holds promise for advancing our understanding of nanotoxicity and facilitating the safe development of nanotechnology-based products and applications.

Published Date: 2024-01-30; Received Date: 2024-01-02