The Influence of Formula Concentration on the Absorption of Darbepoetin Alfa after Subcutaneous Administration

Tomonori Tayama^1*, Kazuki Kawakami¹, Hirotaka Takama¹, Daisuke Nakashima¹, Hideji Tanaka¹, Takayuki Tsuji², Tatsuo Yamamoto³, Sakuo Hoshi⁴ and Tadao Akizawa⁵

¹Development Division, Kyowa Hakko Kirin Company Ltd., 1-6-1 Ohtemachi, Chiyoda-ku, Tokyo, 100-8185, Japan

²1st Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu-shi, Shizuoka, 431-3192, Japan

³Faculty of Health Promotional Sciences, Department of Health and Nutritional Science, Hamamatsu University School of Medicine, 1230 Miyakoda-cho, Kita-ku, Hamamatsu-shi, shizuoka, 431-2102, Japan

⁴Pharmaco-Business Innovation, Graduate School of Pharmaceutical Sciences, Faculty of Pharmaceutical Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan

⁵Department of Nephrology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan