The Effect of Ozone on Collagen Type-1 and Inflammatory Cytokine Production in Human Gingival Fibroblasts

Yoshimasa Makita¹, Yasuhiro Imamura², Kazuya Masuno³, Isao Tamura⁴, Shin-ichi Fujiwara¹, Gotaro Shiota⁵, Akihiko Shiba⁶ and Pao-Li Wang^7*

¹Department of Chemistry, Osaka Dental University, Osaka, Japan

²Department of Pharmacology, Matsumoto Dental University, Nagano, Japan

³Department of Innovation in Dental Education, Osaka Dental University, Osaka, Japan

⁴Department of Oral Anatomy, Osaka Dental University, Osaka, Japan

⁵VMC Co., Ltd., Tokyo, Japan

⁶Department of Prosthodontics, Faculty of Dentistry, Showa University, Tokyo, Japan

⁷Department of Bacteriology, Osaka Dental University, Osaka, Japan