Case Report - (2016) Volume 5, Issue 1

Synchronous Morphologically Distinct Craniopharyngioma and Pituitary Adenoma: A Rare Collision Entity

Harjinder S Bhatoe*, Prabal Deb and Sudip Kumar Sengupta
Institute of Neuroscience, Max Super Speciality Hospital, New Delhi, India, E-mail:
*Corresponding Author: Harjinder S Bhatoe, Institute of Neuroscience, Max Super Speciality Hospital, Patparganj, New Delhi, India Email:


While pituitary tumors and craniopharyngiomas share a common lineage, their simultaneous occurrence is distinctly rare. We present one such patient, an adult male with two distinct tumors, that were excised by two different approaches. Relevant literature is briefly reviewed.

Keywords: Brain tumor; Collision tumor; Craniopharyngioma; Pituitary tumor


Simultaneous occurrence of morphological distinct, discreet intracranial tumors sharing the same cell lineage is a rarity. Pituitary tumors and craniopharyngiomas share a common lineage. Simultaneous occurrence of these two tumors in the same patient is rare and has been reported only nine times so far (Table 1). While pituitary tumours are centred in the sella, craniopharyngiomas may occur anywhere from the pituitary gland to the third ventricle. Association of intra-third ventricular craniopharyngioma and growth hormonesecreting pituitary macroadenoma as two distinct, unconnected tumors occurring synchronously has not been reported so far.

Case Report

A 35-year-old male was admitted with six-month-history of generalized headache, gradual loss of vision and intermittent generalized tonic clonic seizures. Clinically, he had acromegaly and optic atrophy with no perception of light. There was no other neurological deficit. His growth hormone level was 18 ng/ml (normal 1-5 ng/ml).

MRI brain revealed lobulated frond-like solid discreet tumor within the third ventricle causing obstruction to ventricular system and obstructive hydrocephalus. There was no evidence of calcification or hemorrhage. He also had sellar enlargement with homogenously isointense pituitary macroadenoma (Figures 1-3).


Figure 1: Contrast MRI (T1-weighted sagittal) showing intra-third-ventricular craniopharyngioma and pituitary adenoma.


Figure 2: Contrast MRI (T1-weighted coronal) showing intra-third-ventricular craniopharyngioma.


Figure 3: Contrast MRI (T1-weighted axial) showing intra-third-ventricular craniopharyngioma.

He underwent right fronto-parietal minicraniotomy and transcortical transforaminal excision of light coloured, solid, relatively avascular third ventricular tumour. The tumour could be excised completely (Figure 4). Postoperative period was uneventful. MRI three days later did not reveal any residual tumour (Figures 5 and 6). Five days later, he underwent transsphenoidal excision of pituitary adenoma. The tumor was pinkish, soft and vascular.


Figure 4: Resected specimen of craniopharyngioma.


Figure 5: Contrast MRI (T1-weighted sagittal) showing complete excision of third ventricular craniopharyngioma.


Figure 6: Contrast MRI (T1-weighted axial) showing complete excision of third ventricular craniopharyngioma.

Histopathology of the excised third ventricular revealed anastomising epithelial islands with palisading layer of epithelial cells. There were focal areas of calcification, and cystic degeneration (Figure 7). These findings confirmed it to be a craniopharyngioma. Pituitary tumor revealed typical adenoma, while immunohistochemistry confirmed it to be growth hormone-secreting adenoma (Figure 8). Patient was discharged ten days later and referred for postoperative radiotherapy. During the course of follow-up over the past three years, he has remained neurologically static. Vision had not improved.


Figure 7: Histopathology (H & E, X10) showing anastomosing epithelial islands, palisaded layer of epithelial cells and cystic degeneration consisting of keratinous and necrotic material.


Figure 8: Histopathology (H & E, X 10) of top two photographs showing pituitary adenoma. Lower panel shows reticulin stain on the left and immunohistochemistry (GH positivity) on the right.


Multiple intracranial tumors are often considered to be part of neurofibromatoses mosaic, when one of the tumors is a vestibular schwannoma. Tumors occurring at the same site or adjacent anatomical sites may differ on histopathology while retaining the original cell lineage. During embryogenesis, intricate and precise neuroembryological events take place in the sellar region. Both a craniopharyngioma and the pituitary gland share the same embryonic origin, that is Rathke’s pouch, which is a diverticulum of the roof of the embryonic oral cavity. The adenophypophysis is formed from the oropharyngeal duct, while craniopharyngomas arise from the embryological cell rests of an incompletely involuted hypophysealpharyngeal duct [1]. These rests locate on the pituitary stalk anywhere from the tuber cinereum to the pituitary gland. Craniopharyngiomas intrinsic to the third ventricle are thought to arise from tuber cinereum and grow upward into the ventricle [2,3]. Such a tumor arising from the roof of third ventricle is distinctly rare. Both, pituitary adenoma and craniopharyngioma are ontogenetically related, and there is documented evidence of presence of squamous nests with metaplastic potential in the pars tuberalis. A metaplastic change in pituitary adenoma following irradiation can also explain the rare coexistence of pituitary adenoma and craniopharyngioma in the same tumor [4-6]. Only nine well documented cases of coexistence of pituitary adenoma and craniopharyngioma have been reported so far (Table 1) [1,3,4,7-13]. Only in one report, the two tumours were distinct entities [3]. In all others, the two tumor elements were mixed and could be distinctly identified by light microscopy and immunohistochemistry. Interestingly, El-Bilbeisi, et al. [5] reported occurrence of craniopharyngioma in a patient with acromegaly due to pituitary adenoma; the two tumours were separated by a decade.

S. No Reference Craniopharyngioma Pituitary adenoma
1 Hoffman,et al. 1987 [1] Foci of adamantinomatous craniopharyngioma Prolactinoma
2 Cusimano, et al.[3] Suprasellar cystic Microprolactinoma
3 GokdenandMrak[4] Foci of adamantinomatous craniopharyngioma Nonfunctioning adenoma
4 Karavitaki, et al. [7] Adamantinomatous(+Rathke Cleft cyst) Gonadotroph adenoma and Corticotroph adenoma
5 Moshkin, et al.[8] Calcified craniopharyngioma Nonfunctioning adenoma (subtype 3)
6 Prabhakar, et al. [10] Foci of squamous cell rests Hormone profile not available; acromegalic features
7 Sargis, et al. [11] Foci of adamantinomatouscraniopharyngioma Gonadotrophic adenoma
8 Wheatley, et al.[12] Cystic Prolactinoma
9 Yoshida, et al.[13] Foci of adamantinomatous craniopharyngioma Plurihormonal adenoma

Table 1: Reported cases of pituitary adenoma with craniopharyngioma.

The histogenesis of synchronous neoplasms demonstrating two different phenotypes is controversial. There may be coincidental meeting of two different tumors derived from independent tumor stem cells, with or without a shared tumorigenic stimuli. On the other hand there may be a composite mechanism by which a single neoplastic clonal proliferation undergoes divergent differentiation either synchronously or metachronously. There may be metaplastic change in the normal or tumorous tissue. Neoplasms showing dual phenotypes can be explained by one of these theories on the basis of morphologic, immunologic, immunohistochemical or molecular criteria. The prognostic significance of such an association will be known only after accumulation of more data and experience with these cases.

The co-occurrence of craniopharyngioma and pituitary adenoma appears to be a case of ontogenetically related tumors that manifested simultaneously.


Endocrinologically active pituitary adenoma with a pure intrathird- ventricular craniopharyngioma is a rare occurrence. Such an association necessitates precise planning after prioritization of the lesion to be excised. The long-term results are no different from that of the individual lesions.


  1. Hoffman HJ (1994)Surgical management of craniopharyngioma. Pediatr Neurosurg21: 44-49.
  2. Behari S, Banerji D, Mishra A, Sharma S, Chhabra DK, et al. (2003) Intrinsic third ventricular craniopharyngioma: report of six cases and a review of the literature. Surg Neurol60: 245-252.
  3. Cusimano MD, Kovacs K, Bilbao JM, Tucker WS, Singer W (1988) Suprasellar craniopharyngioma associated with hyperprolactinemia, pituitary lactotroph hyperplasia and microprolactinoma. Case report. J Neurosurg69: 620-3.
  4. Gokden M, Mrak Robert E (2009) Pituitary adenoma with craniopharyngioma component. Hum Pathol 40: 1189-1193.
  5. El-Bilbeisi H, Ghannam M, Nimri CF, AhmadAT (2010) Craniopharyngioma in a patient with acromegaly due to pituitary adenoma. Ann Saudi Med 30: 485-488.
  6. Asari J, Yamanobe K, Sasaki T, Yamao N, Kodama M (1987) A case of prolactinoma associated with craniopharyngioma. No ShinkeiGeka 15: 1313-1318.
  7. Karavitaki N, Scheithauer BW, Watt J, Ansorge O, Moschopoulos M, et al. (2008) Collision lesions of the sella: Co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke's cleft cyst with corticotroph adenoma. Pituitary 11: 317-323.
  8. Moshkin O, Scheithauer BW, Syro LV, Velasquez A, Horvath E, et al. (2009) Collision tumors of the sella: craniopharyngioma and silent pituitary adenoma subtype 3. Case report. Endocr Pathol20: 50-55.
  9. Nishioka H, Hirano A, Nakajima N (2002) Histological changes in the pituitary gland and adenomas following radiotherapy. Neuropathology22: 19-25.
  10. Prabhakar V, Rao BD, Subramanyam MV (1971) Pituitary adenoma associated with craniopharyngioma. J Pathol103: 185-187.
  11. Sargis RM, Wollmann RL, Pytel P (2009) A 59-year-old man with sellar lesion. Brain Pathol 19: 161-162.
  12. Wheatley T, Clark TD, Stewert S (1986) Craniopharyngioma with hyperprolactinaemia due to a prolactinoma. J Neurol NeurosurgPsychiat49: 1305-1307.
  13. Yoshida A, Sen C, Asa SL, Rosenblum SK (2008) Composite pituitary adenoma and craniopharyngioma? An unusual neoplasm with divergent differentiation. Amer J Surg Pathol32: 1736- 1741.
Citation: Bhatoe HS, Deb P, Sengupta SK (2016) Synchronous Morphologically Distinct Craniopharyngioma and Pituitary Adenoma: A Rare Collision Entity. Brain Disord Ther 5:207.

Copyright: © 2016 Bhatoe HS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.