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Research Article - (2018) Volume 9, Issue 2

Sex Hormones Effects on the Control of Menopausal Asthma

S. Aissani1*, I. Ararem2, H. Haouichat3, M.E. Haffaf4 and A. Zitouni1
1Department of Pulmonary Service, Mohammed Seghir El Nekkache Hospital, Algeria
2Department of Preventive Medicine, Mohammed Seghir El Nekkache Hospital, Algeria
3Department of Pneumology of Mohammed Seghir El Nekkache Hospital, Algeria
4Department of Nuclear Medicine, Mohammed Seghir El Nekkache Hospital, Algeria
*Corresponding Author: S. Aissani, Department of Pulmonary Service, Mohammed Seghir El Nekkache Hospital, Algeria Email:

Abstract

Introduction: Asthma can persist after menopause but can also occur in pre- or post-menopause. The aging of the bronchial tree and the fall of the hormones during the menopause can influence the control of asthma.

Methods and methods: This is a prospective descriptive study from 2011 to 2017. It involved 106 postmenopausal asthmatic patients divided into two groups according to the onset of asthma before or after menopause. These women received prick tests for the most common allergens, spirometry and a dosage of progesterone and estradiol.

Results: These asthmatics are 45 to 70 years old with an average age of 58.39 ± 7.32 years. They have an average body mass index (BMI) of 28.83 ± 5.68 kg/m2. The almost exclusively passive smoking exposure is found in more than half of the cases.

When asthma occurs after menopause (24 patients), the average BMI is 29.12 ± 4.46 kg/m2. These women were postmenopausal earlier in 12.5% of cases and had positive skin tests in only 23.8% of cases. When asthma occurred before menopause (82 patients), the average BMI was 28.87 ± 5.06 kg/m2. These women have been menopausal at normal age but have decreased respiratory function. Overall uncontrolled asthma was found in 58.5% of patients with postmenopausal asthma and 43.9% in those with pre-menopausal asthma with a statistically significant difference (p=0.04).

There was no significant difference in hormone levels studied between the two groups. But the severity and uncontrolled asthma are associated with significantly higher estradiol levels.

Conclusion: The involvement of estrogen in the control and severity of asthma is not negligible in this study. The possible interaction of these hormones with other field factors such as smoking exposure and obesity is strongly suspected.

Keywords: Asthma; Woman; Menopause; Control; Obesity; Estradiol

Introduction

Asthma can persist after menopause but can also occur in pre- or post-menopause. During this period of the genital life, the asthma coincides with the aging of the respiratory system and the fall of the sex hormones, causing these two factors to be suspected in the uncontrolled asthma. The purpose of our study is search the characteristics of stable menopausal asthma and to determine women at risk of uncontrolled asthma and women who risk asthma after menopause based on sex hormone levels.

Methods

Prospective descriptive study from 2011 to 2017. It covered 106 women with menopausal asthma, aged 45 to 70 years. They are divided into 2 groups according to the onset of asthma before (77.35%) or after menopause (22.64%). They benefited from prick tests for the most common allergens, spirometry and an assay of progesterone and estradiol by radioimmunoassay. We excluded the thyroid, adrenal and gynecological pathologies that can influence the hormone levels as well as cardiovascular pathologies that can increase dyspnea. Final exploitation and data analysis used EPI-DATA analysis software and EPI-INFO6.

Results

The average age of the study population is 58.39 ± 7.32 years. The mean age in the front asthma group is 57.51 ± 7.13 years and in the postmenopausal asthma group is 61.38 ± 7.35 years old and the difference is statistically significant (p=0.02). The average duration of asthma is 25.21 ± 13.7 years when asthma appeared before menopause. It is 6.75 ± 4.04 years old when asthma appears after menopause and the difference is significant (p=10-4).

Most women were menopausal at normal ages between 45 and 55 years of age (Figure 1). Early menopause is more common in postmenopausal asthma in 12.5% of patients. As for late menopause, it is more common in case of asthma before menopause: 34.1% of cases (Figure 1). The average age of menopause in pre-menopausal asthma is 49.04 ± 4.36 years and in menopausal asthma, it is 46.04 ± 6.34 years with a statistically significant difference (p=0.009).

allergy-therapy-Age-menopause

Figure 1: Age of menopause

The average body mass index (BMI) of the study population is 28.83 ± 5.68 kg/m2. In case of asthma after menopause, overweight is found in 45.8% of cases and obesity in 37.5% of cases (Figure 2). In case of asthma before menopause, overweight is found in 40.2% of cases and obesity in 35.5% of cases. In addition, the average body mass index (BMI) for asthma before menopause is 28.87 ± 5.06 kg/m2 and it is 29.12 ± 4.46 kg/m2 in case of asthma after menopause (p=0.82).

allergy-therapy-Body-mass

Figure 2: Body mass index (BMI)

There was no difference between the two groups of asthma in terms of exposure to tobacco and biomass. There is also no difference in the nature and number of comorbidities (Table 1). Moderate asthma dominates in both groups, and severe asthma is more common in those with pre-menopausal asthma (Figure 3).

allergy-therapy-Asthma-severity

Figure 3: Asthma severity

    Before menopause (N=82) After menopause (N=24) P
Smoke Smoke exposure 37 (41.12%) 13 (54.16%) 0.75
-ACTIF
-PASSIF
2 (2.4%)
35 (46.3%)
1 (4.2%)
12 (50%)
0.83
Biomass exposure 14 (17.1%) 5 (20.8%) 0.67
Comorbidition Presents 63 (76.8%) 21 (87.5%) 0.25
Gastroesophageal reflux 51 (62.2%) 18 (75%) 0.24
Rhino-sinusitis 78 (95.1%) 21 (87.5%) 0.13
Conjunctivitis 59 (72%) 16 (66.7%) 0.61

Table 1: Smoke and comorbidities

Uncontrolled asthma is frequently found in women with premenopausal asthma (Figure 4).

allergy-therapy-Asthma-control

Figure 4: Asthma control

When grouping patients with partially controlled asthma and uncontrolled asthma, overall non-control was found in 58.5% of patients with asthma after menopause and 43.9% in the other group with a statistically significant difference (p=0.04). This no control is more common in women over 65 (35.7% of cases) and in the age group 45-55 in 42.9% of cases (Figure 5).

allergy-therapy-age-groups

Figure 5: Asthma control according to age groups

The concept of familial atrophy was found in 87.8% of women who had asthma before menopause and in 83.3% of cases whose asthma appeared after menopause (p=0.59). Skin tests were performed in only 80 women (75.47%): 59 asthmatics who had pre-menopausal asthma (71.95%) and a positive result in 54.2% and were did in 21 asthmatics with asthma after menopause (87.5%) with positive tests in only 23.8% and the difference between the two groups is statistically significant (p=0.01). The analysis of spirometry found a lower rate of FEV1/CV ratio and peripheral flow rates (FEF 50, FEF25 and FEF 25-75) in asthma before menopause (Table 2).

  Asthma before menopause Value [IC 95%] (N=82) Asthma after menopause Value [IC 95%] (N=24) P
VC (I) 2.44 [2.33-2.55] 2.34 [2.08-2.59] 0.39
FVC (I) 2.40 [2.29-2.5] 2.31 [2.05-2.57] 0.46
PEF (I/s) 4.90 [4.64-5.16] 4.95 [4.3-5.59] 0.87
FEV1 (I) 1.94 [1.83-2.04] 2.01 [1.78-2.25] 0.46
FEV1/VC (%) 79.62 [77.81-86] 86.67 [83.05-90.28] 0.002
FEF75 (I) 4.01 [3.69-4.34] 4.57 [3.89-5.25] 0.11
FEF50 (I) 2.41 [2.14-2.67] 2.95 [2.45-3.45] 0.05
FEF25 (I) 0.95 [0.83-1.08] 1.31 [0.96-1.65] 0.01
FEF25-75 (I) 2.05 [1.82-2.28] 2.56 [2.09-3.05] 0.03

Table 2: Spirometer results

The average progesterone level in postmenopausal asthmatics is normal by laboratory standards. On the other hand, the average level of estradiol is higher, especially among those who have had asthma after menopause and are at a distance from the beginning of menopause. In addition, the mean estradiol level of the study population is greater than the mean value of the normal population (Table 3).

  Asthma before menopause Value [IC 95%] (N=82) Asthma after menopause Value [IC 95%] (N=24) P
Progesterone (nmol/I) 0.65 [0.23-1.08] 0.33 [0.13-0.61] 0.50.
Normal value of progesterone 1 [0.5-5.20]
Estradiol (pg/ml) 135.49 [32.52-238.41] 62.42 [38.10-86.74] 0.45
Normal value ofEstradiol 26 [11-50]

Table 3: Hormone level

The mean level of estradiol is significantly higher in severe and/or uncontrolled asthma. Progesterone levels were not associated with the severity stages of asthma (Tables 4 and 5).

  Intermittent [IC 95%] N=3 Mild [IC 95%] N=3 Moderate [IC 95%] N=3 Severe [IC 95%] N=3 P
Progesterone (nmol/I) 1.01 [1.25-3.47] 0.73 [0.50-0.95] 1.19 [0.70-1.67] 0.78 [0.35-1.2] 0.67
Estradiol (pg/ml) 159.77 [50-720.01] 73.94 [39.11-108.78] 56.45 [43.49-69.41] 221.99 [117.16-482.9] 0.003

Table 4: Hormone levels according to the asthma severity

  Controlled Value [IC 95%] (N=56) Partially control Value [IC 95%] N=36 Uncontrolled Value [IC 95%] N=14 P
Progesterone (nmol/I) 0.83 [0.65-1.02] 1.16 [0.53-1.78] 1.5 [0.33-3.52] 0.23
Estradiol (pg/ml) 69.94 [46.62-88.71] 60.06 [39.83-80.29] 181.98 [20-383.98] 0.01

Table 5: Hormone levels according to the asthma control

Discussion

This work made the following observations: Asthma is more severe and less controlled in women who have had asthma after menopause; what has already been reported by GIBBS [1] and FOSCHINO [2]. Uncontrolled asthma is more common in women aged 46 to 55, generally corresponding to the age of onset of menopause (42.9% of cases). It is also common in people over 65 who are far from the beginning of menopause (35.7% of cases). This makes it possible to consider these two age groups as two particular phenotypes in the severity and uncontrolled asthma.

Uncontrolled asthma is due to several factors including obesity. The majority of menopausal asthmatics are overweight or obese. The average body mass index is higher for asthma after menopause. This excess weight is one of the reasons for the non-control observed in the menopause since it has been shown for several years that overweight and obesity are responsible for the severity and uncontrolled asthma [3-5]. It has even been shown by TRIEBNER that the risk of asthma after menopause is related to obesity and that this risk is higher when asthma appears at a distance from menopause with a higher Odds Ratio of 26.15 [IC 95%: 2.62-261.13]. This makes it possible to consider the combination of obesity and asthma after menopause as a particular phenotype [6].

Tobacco exposure is already mentioned in the literature as a factor influencing the control of asthma [7,8]. This was a passive smoking exposure in the majority of our patients (Table 1). Tobacco may be a factor responsible for the precocity of menopause [9]. It leads to an increase in bronchial hyper reactivity with the risk of asthma [8]. This may partly explain why asthma occurred after menopause, as 54.16% of women with postmenopausal asthma had tobacco exposure. These women were postmenopausal earlier than those who had asthma before menopause and who were less exposed to tobacco (exposure in 41.12% of cases).

In addition, asthma after menopause is often non-allergic. This has already been reported in the literature [10-13] and found in our work. For this reason, the onset of asthma after menopause often causes other non-allergic factors such as obesity, smoking, external environmental and household factors to be suspected. It may even be secondary to the effect of aging on the respiratory system and/or the age of the disease, especially since there has been a significant decrease in respiratory function in the case of asthma before menopause. The difference between asthma groups before and after menopause exists clinically and allergically but does not by itself explain the occurrence of asthma after menopause. A hormonal cause is possible but no significant difference in hormone levels was found between the asthma groups before and after menopause.

Whether it is asthma before or after menopause, the average levels of estradiol are higher than the average rate of the laboratory standard. WEINSTEIN found lower rates in postmenopausal asthmatics compared with non-asthmatics with an average rate of 4.4 pg/ml [14]. This result is not contradictory to ours. It is explained by the lower average age of our patients compared to that of WEINSTEIN (58.39 ± 7.32 years vs. 67.8 ± 7.7 years), since the further away the peri menopause and the lower the estradiol level is high.

Other authors such as GRAHAM BARR [15] and KOS-KUDLA [16] have found low levels of estradiol in menopausal asthmatics. But these authors have measured the sex hormones in asthmatics with hormonal substitution, which could influence the result. In our series, only one patient had received hormone replacement therapy, which does not allow conclusions to be drawn about the effect of hormonal substitution on asthma.

The high mean estradiol level observed in our menopausal patients may be due to the transformation of androgens into estrogens from adipose tissue [17,18] in our overweight or obese patients fat is very important.

In addition, the severity and uncontrolled asthma is significantly associated with a higher level of estradiol, suggesting that the pro-inflammation effect of high estradiol [19]. Thus obesity has a dual influence on bronchial inflammation by action on adipocytes to stimulate mediators of inflammation [20] and on the indirect increase of estradiol levels by transformation of androgens into estrogens from the tissue adipose [18]. The consequence would be an increase in bronchial inflammation with uncontrolled asthma.

Conclusion

In this work, there was no individuality in terms of hormonal dosage between those who had asthma after or after menopause. But asthma severity and non-control are significantly related to higher levels of estradiol suggesting the involvement of estradiol in the pathophysiology of postmenopausal asthma. While obesity and smoking have been found in our work as factors associated with asthma after menopause, the interaction of these two factors with sex hormones may explain the onset of asthma after menopause. Postmenopausal women's asthma is unique because of the association of several factors: comorbidities, obesity, lack of physical activity and deterioration of the psyche that must be taken into account.

References

Citation: Aissani S, Ararem I, Haouichat H, Haffaf ME, Zitouni A (2018) Sex Hormones Effects on the Control of Menopausal Asthma. J Allergy Ther 9: 275.

Copyright: © 2018 Aissani S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.