Pilin Vaccination Stimulates Weak Antibody Responses and Provides No Protection in a C57Bl/6 Murine Model of Acute Clostridium difficile Infection

Grace A Maldarelli¹, Hanover Matz¹, Si Gao², Kevin Chen², Therwa Hamza², Harris G Yfantis³, Hanping Feng² and Michael S Donnenberg^1*

¹Department of Medicine, Division of Infectious Disease, University of Maryland School of Medicine, Baltimore, Maryland, USA, E-mail: mdonnenb@umaryland.edu

²Department of Microbial Pathogenesis, University of Maryland Dental School, Baltimore, Maryland, USA, E-mail: mdonnenb@umaryland.edu

³Department of Pathology and Laboratory Medicine, VAMHCS, University of Maryland School of Medicine, Baltimore, Maryland, USA, E-mail: mdonnenb@umaryland.edu