EZH2 and Sonic Hedgehog Inhibition Reduce Proliferation, Migration, In Vitro Tumorigenesis, and CD133 Expression in Desmoplastic Medulloblastoma Cells

Javier De La Rosa¹, Leire Tapia¹, Mehdi H Shahi², Bárbara Meléndez³, Juan A Rey⁴, Miguel A Idoate⁵ and Javier S Castresana^1*

¹Department of Biochemistry and Genetics, University of Navarra School of Sciences, Spain

²Faculty of Medicine, Interdisciplinary Brain Research Centre, Aligarh Muslim University, India

³Molecular Pathology Research Unit, Virgen de la Salud Hospital, Spain

⁴IdiPaz Research Unit, La Paz University Hospital, Spain

⁵Department of Pathology, University of Navarra Clinic, Spain