Alpha-1-Antitrypsin Deficiency Presenting as Neonatal Cholestasis: Predictors of Outcome and Effect of Ursodeoxycholic Acid

Ermelinda Santos Silva^1,2*, Helena Moreira Silva², Cláudia Melo³, Herculano Rocha⁴, Margarida Medina⁴ and Esmeralda Martins^1,5

¹Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua Jorge Viterbo Ferreira, no 228, 4050-313 Porto, Portugal

²Paediatric Gastroenterology Service, Department of Child and Adolescent Medicine, Centro Hospitalar do Porto, Largo Abel Salazar, 4099-001 Porto, Portugal

³Paediatric Service, Unidade Hospitalar de Famalicao, Centro Hospitalar do Médio Ave, Rua de Cupertino de Miranda, 4764-958 Vila Nova de Famalicão, Portugal

⁴Paediatric Service, Department of Child and Adolescent, Centro Hospitalar do Porto; Largo Abel Salazar, 4099-001 Porto, Portugal

⁵Metabolic Diseases Unit, Paediatric Service, Department of Child and Adolescent, Centro Hospitalar do Porto; Largo Abel Salazar, 4099-001 Porto, Portugal