Indexed In
- Genamics JournalSeek
- JournalTOCs
- CiteFactor
- Ulrich's Periodicals Directory
- RefSeek
- Hamdard University
- EBSCO A-Z
- Directory of Abstract Indexing for Journals
- OCLC- WorldCat
- Publons
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Journal Flyer
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Abstract
The Effect of Nutritional Supplementation with Curcumin on RANKL/OPG Ratio in Gingival Crevicular Fluid of Chronic Periodontitis Patients: A Randomized Controlled Trial.
Sushma Reddy Bhavanam, Krishna Kripal*, Shanmugapriya PA, Kavita Chandrasekaran
Background and Objectives: Although periodontitis is an infectious disease of the periodontium, changes that occur in bone are critical because the destruction of bone is responsible for tooth loss. A key system for controlling bone turnover is the RANK-RANKL-OPG system. Curcumin is a polyphenol with antioxidant, anti-inflammatory properties which has an inhibitory effect on NF κß. As an attempt to assess the effect of Curcumin on RANKL/OPG ratio levels in chronic periodontitis patients, this study was done to evaluate the effect of nutritional supplementation with curcumin on RANKL/OPG ratio in the gingival crevicular fluid of chronic periodontitis patients.
Methodology: The study was conducted in the Department of Periodontology, Rajarajeswari Dental College and Hospital. A total of 60 patients, Group I with 30 subjects, receiving a scaling and root planing and curcumin supplements in the form of tablets twice (500 mg) a day for 6 weeks. Group II with 30 subjects, receiving scaling and root planning and placebo twice a day for 6 weeks. All clinical parameters were recorded and GCF was collected from all the subjects at baseline and at 6 weeks after treatment to estimate the levels of RANKL/OPG ratio by ELISA
Results: In the test group there was a significant decrease in a GI, PI, PD, CAL from baseline to 6 weeks. In both the groups there was a decrease in the RANKL/OPG ratio from baseline to 6 weeks after treatment but the decrease in the test group was more statistically significant.
Conclusion: Nutritional supplementation with curcumin showed a significant decrease in clinical parameters and also RANKL/OPG ratio at 6 weeks after treatment. Hence curcumin can be used as an adjunct in the treatment of periodontal diseases.
Published Date: 2020-02-17; Received Date: 2020-01-22