The Clostridium perfringens epsilon toxin made by the microorganism true bacteria could be a doubtless fatal bioterrorism weapon. If used effectively, this agent might cause important morbidity and mortality and, because of a scarcity of existing analysis into the result of this poison in humans, no therapeutic or preventive measures exist as medical countermeasures. Notable well for manufacturing severe medicine malady in domestic mammals, Clostridium perfringens epsilon toxin might be promptly weaponized and dispersed via AN orally ingestible or aerosol route. This critical review considers the present literature and tries to position stress on understanding this organism and this poison in its rightful place as AN agent of goodly concern to be used in act of terrorism attacks. The review includes a discussion of the bacteria genus, the precise toxins of C. perfringens in addition as focusing on Clostridium perfringens epsilon toxin above all.