The Centrosome: A Phoenix Organelle of the Immune Response

Anastassiia Vertii and Stephen Doxsey

Stress exposure influences the function, quality and duration of an organism’s life. Stresses such as infection can induce inflammation and activate the immune response, which, in turn, protects the organism by eliminating the pathogen. While many aspects of immune system functionality are well established, the molecular, structural and physiological events contributed by the centrosome remain enigmatic. Here we discuss recent advances in the role of the centrosome in the stress response during inflammation and the possible benefits of the centrosome as a stress sensor for the organism.