Modern Chemistry & Applications

Abstract

Synthesis and Characterization of Schiff Base CoII, NiII and CuII Complexes Derived from 2-Hydroxy-1-naphthaldehyde and 2-Picolylamine

Kadhiravansivasamy K, Sivajiganesan S, Periyathambi T, Nandhakumar V, Chidhambram S and Manimekalai R

New Co^II, Ni^II and Cu^II complex has been synthesized and characterized by elemental analysis, UV-Vis, FT-IR and thermal analysis. binding of this Co^II, Ni^II and Cu^II complex with calf thymus DNA was investigated by UV-Visible absorption, fluorescence spectroscopy techniques. The intrinsic binding constants K_b of complex with CT-DNA obtained from UV-Vis absorption studies were 4.43 × 10⁵ M^-1. Further, the in vitro cytotoxic effect of the complexes examined on cancerous cell line, such as human breast cancer cells (MCF-7).