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Abstract
Pre-Formulation and Formulation Approaches for Buccal Films
Many potential active pharmaceutical ingredients (APIs), which are drugs of abuse, or as recreational drugs, and which have narrow therapeutic index causing hundreds of deaths in recent years can be casted into buccal films. Many drugs which are lipophilic, and which can easily penetrate the blood–brain barrier can be of choice for buccal delivery. The bio-adhesive film for buccal delivery has advantage of the control delivery and has higher permeability, and lower reservoir capacity, of the epithelium. A simple system, consisting of a drug-loaded bio-adhesive coated onto an impermeable backing layer, can be easily envisaged.