20+ Million Readerbase
Indexed In
  • Open J Gate
  • Genamics JournalSeek
  • JournalTOCs
  • Ulrich's Periodicals Directory
  • RefSeek
  • Hamdard University
  • EBSCO A-Z
  • OCLC- WorldCat
  • Proquest Summons
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • Google Scholar
Share This Page
Recommended Webinars & Conferences

21st World Hematology Congress

Madrid, Spain

29th International Oncology Summit

Chicago, USA

37th Global Summit on Pediatrics

Madrid, Spain

14th Annual Conference on Stem Cells and Regenerative Medicine

Kuala Lumpur, Malaysia
Journal Flyer
Flyer image

Abstract

Oxidative Stress as Marker of Sepsis in Onco Hematological Patients: A Pilot Study

Fracchiolla NS, Cortelezzi A, Orofino N, Novembrino C, De Giuseppe R, Turrini M and Bamonti F

Background: Oxidative status can be altered in cancer.

Objective: To evaluate the role of oxidative stress as plasma biomarker able to predict sepsis severity in oncohaematological patients experiencing infections after chemotherapy.

Methods: Spectrophotometric measurement of Reactive oxigen metabolites (ROMs) levels and Total antioxidant capacity (TAC) in 15 patients prospectively enrolled and 52 healthy volunteers.

Results: ROMs baseline values were higher in patients and raised during fever. Severe sepsis was associated with the highest degree of ROMs increase. TAC levels were always low, both at baseline and during infection.

Conclusions: Our results confirm oxidative status derangement during post-chemotherapy infections. ROMs concentrations could represent an easily detectable biomarker correlated with sepsis severity in post-chemotherapy neutropenia.