Journal of Biomolecular Research & Therapeutics

Abstract

O-Glcnac Glycosylation of Rad51 Plays an Important Role in Promoting Colorectal Cancer Cell Invasion

Qinghua Li, Zhuangzhi Cong, Yongkang Yang, Xinlai Guo, Longjiu Cui, Tiangeng You and Weifeng Tan

Colorectal cancer (CRC) metastases accounts for two thirds of death cases. Recently, genetic instability has been recognized as one of the hallmarks of metastatic microenvironment. In this study, we identified the relationship between Rad51, a key factor to perform DNA homologous recombination repair, and CRC metastasis, and further at the first time explored the effect of O-GlcNAc glycosylation of Rad51 protein on CRC cells invasion. Generally, the study indicates a novel posttranslational modification of Rad51 protein may play an important regulatory role in the process of CRC cells invasion and represent a potential therapeutic target for clinical management of CRC patients.