Molecular Mechanism of Tumorigenesis and Biomarkers of Opisthorchiasis-associated Cholangiocarcinoma

Zhiliang Wu and Thidarut Boonmars

Definitive relationship has been confirmed between Opisthorchis viverrini infection and tumorigenesis of cholangiocarcinoma (CCA), by epidemiological investigation and animal experiments. In the O. viverrini endemic area, opisthorchiasis-associated CCA has been becoming a serious public health problem. Understanding of the molecular mechanisms of tumorigenesis of the infection-induced CCA will be helpful to develop new biomarkers for diagnosis and therapy. This review addresses recent progresses in molecular mechanism and biomarker of opisthorchiasisassociated CCA.