Journal of Psychiatry

Abstract

Microstructural white matter changes in Alzheimer?s disease

Pajavand A M

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive decline. Current study used diffusion tensor imaging data from the Alzheimer's disease neuroimaging initiative 2 databases to examine microstructural white matter changes in individuals with Alzheimer's disease relative to healthy controls.

Introduction:

Alzheimer’s disease (AD) is a gradual progressive neurodegenerative disorder in which memory deficit is typically the most salient cognitive symptom. Patients with amnestic mild cognitive impairment (aMCI) are at higher risk of developing Alzheimer’s disease (AD) where aMCI is frequently considered as an early stage of Alzheimer’s disease (AD). Converging evidence suggests that both Alzheimer’s disease (AD) and aMCI are associated with the large-scale functional network dysconnectivity. Especially in the default mode network (DMN) which consists of the posterior cingulate cortex (PCC), precuneus, medial prefrontal cortex (mPFC), and bilateral angular gyrus4. DMN dysconnectivity is often associated with the worsened memory. In parallel grey matter volume (GMV) loss in the medial temporal lobe (MTL) and DMN regions are typically related to the memory decline in Alzheimer’s disease (AD) patients.

Published Date: 2021-03-29;