Diabetes Case Reports

Abstract

Kinetics of Post-Exercise Excess CO2 Production and Substrate Oxidation in Two Dysglycemic and Euglycemic Older Women A Case Study.

Andrei Gribok, William Rumpler and Loretta DiPietro

We examine the case of post-exercise excess CO2 production and instantaneous substrate oxidation in two older women, one with impaired glucose tolerance and the other one is euglycemic. Both subjects stayed in the room-size calorimeter for 48 hours and performed three bouts of postprandial exercise on the second day. The instantaneous gas exchange rates have been estimated along with the instantaneous respiratory exchange ratio (RER) for the whole 48- hour experiment. The relative dynamics of O2 consumption and RER showed a greater reliance on the carbohydrate as energy source in dysglycemic woman than in euglycemic woman. Also, the rate of post-exercise excessive CO2 output, quantified as the time lag between peaks in O2 consumption and peaks in RER was found to be higher in dysglycemic woman suggesting heavier reliance on anaerobic metabolism during exercise. For the first time, results relating the excess post-exercise CO2 production and impaired glucose tolerance are presented.