Correct treatment of anaphylaxis in emergency events is a key point to prevent death and subsequent events. Anaphylaxis can be quickly diagnosed if we recognize respiratory and circulatory manifestations and we correctly assess mental status. The first and most important treatment is epinephrine. After successful therapy, the clinician’s attention must be directed toward preventing recurrences- biphasic anaphylaxis and to elucidate the causes. The patient will need to be explained the importance of preventing relapse and needs to be equipped with epinephrine, which to use in critical situations. There are differences concerning therapeutic approach, recognition of symptoms and patient education, depending on physician’s experience, on patient’s education level and on socio-economic level of their country.