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Classic Radionuclide 188W/188Re Generator (Experiments, Design and Construction)

Marcin Konior and Edward Iller

Rhenium-188 belongs to the group of beta-gamma emitters. A radiometric characteristic of radiation emitted by Rhenium-188 creates advantageous conditions for medical applications of this radionuclide. The Radioisotope Center Polatom Poland has developed and implemented the technology for routine production of carrier free 188Re. A production line for the preparation of sterile, isotonic solution carrier-free 188Re sodium perrhenate (VII) has been constructed. On the basis of collected experiences, the manufacturing of 188W/188Re generators, in which chromatographic column is loaded with alumina has been established. At the present time the generators with activity of 3.7-37 GBq are available.