Awards Nomination
20+ Million Readerbase
PMC/PubMed Indexed Articles
Indexed In
- Academic Journals Database
- Open J Gate
- Genamics JournalSeek
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- Scimago
- Ulrich's Periodicals Directory
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- MIAR
- University Grants Commission
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Abstract
Chimeric Protein PSPF, a Potential Vaccine for Prevention Streptococcus pneumoniae Infection
Suvorov A, Dukhovlinov I, Leontieva G, Kramskaya T, Koroleva I, Grabovskaya K, Fedorova E, Chernyaeva E, Klimov N, Orlov A and Uversky V
A chimeric protein, designated PSPF (Pneumococcus Surface Proteins and Flagellin) was constructed from conservative and immunogenic fragments of S. pneumoniae surface proteins PspA, Spr1875, PsaA and the Salmonella typhiurium flagellin terminal domains FliC1, FliC2 functioning as adjuvant. PSPF was highly immunogenic in mice and induced protection from virulent S. pneumonia strains. All the subtypes of S. pneumoniae under study were recognized by anti-PSPF sera. Thus, the chimeric recombinant PSPF protein is a promising vaccine candidate for immunization of humans against S. pneumoniae.