Centrosome Centering and Decentering by Microtubule Network Rearrangement

Gaëlle Letort and Mithila Burute

Seeing is believing but not necessarily understanding. Advances in microscopy techniques have allowed us to watch cellular machinery at work. For example, sequence of events imaged during cell division revealed important cytoskeletal and shape transformation of cell. Understanding how forces that bring about spindle pole movement are balanced during cell division requires additional tweaking to the system than mere observations. Elegant experimental setup such as laser microsurgery or optical tweezers can be used to identify components of force balance.