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Cartilage Oligomeric Matrix Protein as New Marker in Diagnosis of Rheumatoid Arthritis

Mohamed I Aref and Hamdy Ahmed

Rheumatoid arthritis (RA) is the most common systemic inflammatory autoimmune disease of unknown etiology. The early in diagnosis of RA is crucial. To facilitate diagnosis during the early stages of RA, when often not all clinical symptoms are manifest, a good serological marker is needed. Among serological markers are rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) C-reactive protein (CRP), anti-cyclic citrullinated peptites (anti-CCP) and cartilage oligomeric matrix protein (COMP). A comparison between those markers in respect to the accuracy was the aim of this study.

Patient and methods: Sixty patients with RA and auto-immune non-RA were selected for this study compared with 20 normal healthy persons. The results showed both COMP and anti-CCP can be help for diagnostic value than other selected parameter.