The antibiotics resistant micro-organism has increased in past three decades. The Methicillin Resistant Staphylococcus aureus (M.R.S.A) and Vancomycin resistant Enterococcus faecalis (VRE) is a problematic in the field of medical science. This organism tends to cause serious infection in the burnt patients and mortality. MRSA is a major nosocomial pathogen. Thereby our study aims to control these micro-organisms using various plants extracts. Four plant species Ageratum conyzoides, Phyllanthus emblica, Camellia sinensis and Mentha longifolia were collected and subjected to ethanolic extraction. The ethanolic extracts were tested against clinically isolated multidrug resistance Enterococcus faecalis and Staphylococcus aureus. The ethanolic plants extracts were prepared at variable concentrations for Staphylococcus aureus and Enterococcus faecalis. In view of MRSA against clinically isolated Staphylococcus aureus and Enterococcus faecalis the concentration based analysis showed the zone of inhibition against the selected micro-organism in which Camellia sinensis was found potent against Staphylococcus aureus and Mentha longifolia against Enterococcus faecalis. In future after the detailed study it can be used as a potent biochemical drugs to overcome the infections caused by these organisms.