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Analysis of Rh Blood Type Antibody Specificities of Transfused Patients in the Sichuan Area of China

Cuiying Li, Li Zhang, Fei Huang, Jie Xiao, Hong Xu and Zhewen He

Objective: Rh blood type antibody specificities of transfused patients in the Sichuan area of China were analyzed to reduce immune haemolytic transfusion reactions and improve the safety of clinical blood transfusion.
Methods: The micro-column gel method was introduced to screen irregular antibodies in patient blood samples between June 2015 and June 2006 in our hospital. The antibody specificities of antibody-positive samples were identified, and the type and proportion of antibodies were analyzed.

Results: A total of 130,866 samples of transfused patients were tested. The number of irregular antibody-positive cases was 1127 (positive rate=0.86% [1127/130,866]). The number of specific antibody cases was 576 (positive rate=51.11% [576/1127]). Among the positive cases, Rh type antibodies were shared in 78.29% of patients (451/576) and the number of anti-E cases was 358; Rh type antibodies existed in 79.37% of patients (358/451). The number of patients without a history of blood transfusion and pregnancy was 103; Rh type antibodies were shared 28.77% (103/358) in all anti-E cases.
Conclusion: It is very important to screen for red cell irregular antibodies, especially Rh type antibody, before transfusion. The detection of Rh (E) antigen in transfused patients and transfusion with the same type blood are also important.