Journal of Clinical Research & Bioethics

Abstract

A Study of Lipid Profile and Lipid Peroxidation in Chronic Kidney Disease with Special Reference to Hemodialysis,

D.S.S.K.Raju, D.L.Lalitha and P. Kiranmayi

Chronic Kidney Disease (CKD) exhibits dyslipidemia and oxidative stress which are well known traditional risk factors for vascular complications. Therefore this study was undertaken to assess the lipid profile and oxidative stress in CKD patients. The study comprised of 95 patients with evidence of CKD. These cases were further divided into 2 groups i.e. non dialysis and hemodialysis groups. There is a significant increase of serum triglycerides and Very Low Density Lipoprotein (VLDL) with a decrease in serum High Density Lipoprotein–Cholesterol (HDL-C) in both non dialysis and hemodialysis groups of CKD patients when compared with control. But there is no alteration in serum total cholesterol and Low Density Lipoprotein Cholesterol (LDL-C) in both groups. Serum Malondialdehyde (MDA) was significantly raised and serum Superoxide Dismutase (SOD) was significantly lowered in CKD patients both in non dialysis and hemodialysis groups when compared with control. The same changes in respect of serum Malondialdehyde (MDA) and Superoxide dismutase (SOD) were also noted in hemodialysis group when compared with non dialysis patients. In hemodialysis patients, the alteration was further aggravated after hemodialysis and these changes were found to be significant when compared with those patients before hemodialysis. All these factors are suggestive of abnormal lipid profile and enhanced lipid peroxidation with decreased antioxidant status. This study would be beneficial for patients with CKD especially those under hemodialysis for instituting antilipidemic drugs and antioxidant therapy which will improve the quality of their lives.